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  • Antiphospholipid antibody syndrome

    Antiphospholipid antibody syndrome: An immune disorder characterized by the presence of abnormal antibodies in the blood associated with abnormal blood clotting, migraine headaches, recurrent pregnancy losses (repeat spontaneous abortions), and low blood platelet counts (thrombocytopenia).

    The abnormal antibodies are directed against phospholipids. (Phospholipids are fats that contains phosphorous). APLS can occur by itself (primary) or be caused by an underlying condition (secondary), such as systemic lupus erythematosus. About a third of persons with primary APLS have heart valve abnormalities.

    Antiphospholipid antibodies reduce the levels of annexin V, a protein that binds phospholipids and...

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